Atypical Hemolytic Uremic Syndrome Recurrence after Renal Transplantation
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منابع مشابه
Atypical Hemolytic Uremic Syndrome Recurrence after Renal Transplantation
Risk for atypical hemolytic uremic syndrome (aHUS) recurrence after renal transplantation is low with an isolated membrane cofactor protein mutation (MCP). We report the case of a 32-year-old woman with a MCP who underwent kidney transplantation with a good evolution at 12 months. At 15 and 35 months, 2 episodes of thrombotic microangiopathy (TMA), after a miscarriage and a preeclampsia, were m...
متن کاملProphylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome.
To the Editor: Atypical hemolytic–uremic syndrome is a rare microangiopathic hemolytic condition characterized by thrombocytopenia and acute renal failure.1 The prognosis for patients with atypical hemolytic–uremic syndrome with a factor H mutation is poor; 60% have end-stage renal disease or die within a year.2 The expected rate of graft failure due to recurrent atypical hemolytic–uremic syndr...
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There is a significant risk of disease recurrence in patients with diarrhea-negative hemolyticuremic syndrome undergoing renal transplantation. Considering the low frequency of hemolyticuremic syndrome among adults with end-stage renal disease, only a few reports are available on the outcome of these patients after renal transplantation. It has been suggested, though not proven, that living rel...
متن کاملAtypical Hemolytic Uremic Syndrome
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described. Incomplete penetrance of mutations in all predisposing genes is r...
متن کاملAtypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Most cases of aHUS are caused by uncontrolled complement activation due to genetic mutations in the alternative pathway of complement. More recently, mutations in the gene of coagulation system have also been identified in...
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ژورنال
عنوان ژورنال: Transplantation Direct
سال: 2015
ISSN: 2373-8731
DOI: 10.1097/txd.0000000000000518